Here you will find presentations given at COMSOL Conferences around the globe. The presentations explore the innovative research and products designed by your peers using COMSOL Multiphysics. Research topics span a wide array of industries and application areas, including the electrical, mechanical, fluid, and chemical disciplines. Use the Quick Search to find presentations pertaining to your application area.

Design and Optimization of Cholesterol Biosensor

N. M. Sundaram[1], M. Alagappan[1]
[1]PSG College of Technology Coimbatore, Tamil Nadu, India

Cholesterol is an essential lipid for human body. The desired total plasma cholesterol for an individual is less than 5.2 mM (200 mg/dL) and it poses a potential health threat when the level is greater than 6.2 mM (240 mg/dL) [1]. Excessive plasma cholesterol causes poor cardiovascular conditions. The experimental fabrication of nano structured biosensor with advanced materials is more expensive ...

Physical and FEM Simulation of Microprobe Insertion into Brain Tissue

A. Eed Olamat, U. Hofmann, B. Pohl, and N. Nkemasong
University of Lübeck, Institute for Signal Processing, Lübeck, Germany

In order to investigate the implantation of microprobes into brain tissue, we developed a finite-element and a physical model to replace real biological tissue for mechanical testing. Penetrating forces of a tungsten indenter into a layered structure was investigated with different indentation speeds. Numerical and physical model are in good correspondence to each other and reproduce measured ...

Design of Microneedle Array for Biomedicine

N. Mane[1], A. Gaikwad[1]
[1]Department of Instrumentation, Cummins College of Engineering, Pune, Maharashtra, India

Micro electro-mechanical system (MEMS) is rapidly growing area of interest for a broad spectrum of applications. One particularly fast-growing area is biomedical applications for micromaching technologies. One application of interest to the biomedical industry is the development of microneedles. MEMS technology brings new means for biomedicine field. Patch-based transdermal drug delivery offers ...

A Multiscale-Multiphysics Model for Axon Pathfinding Simulation, the Example of the Olfactory System

G. Naldi[1], G. Aletti[1], P. Causin[1]
[1]Dipartimento di Matematica ‘F. Enriques’, Università degli Studi di Milano, Milano, Italy

In the developing embryo, neurons form connections by projecting axons to appropriate target areas. The projection process includes neurite elongation, resulting from the assembly of new cytoskeletal material at the free end of the axon, a complex cascade of steering decisions, driven by biomechanical properties of the surrounding environment and by signals in it. In this work we focus on the ...

Simulation of Convection in Water Phantom Induced by Periodic Radiation Heating

H.H. Chen-Mayer[1], and R. Tosh[1]
[1]Ionizing Radiation Division, National Institute of Standards and Technology, Gaithersburg, Maryland, USA

Water calorimetry is employed to establish a primary reference standard for radiation dosimetry by measuring the temperature rises in a water phantom (a cube of about 30 cm x 30 cm x 30 cm) subjected to a beam of ionizing radiation.  We use COMSOL Multiphysics to model the system using the Heat Transfer module and the Incompressible Navier-Stokes module with a geometry of 2D-axial ...

Modelling of Thermally Induced Electrical Instabilities in Intestine using COMSOL Multiphysics®

A. Gizzi[1][3], C. Cherubini[1][2], S. Migliori[1][3], and S. Filippi[1][2]
[1]Nonlinear Physics and Mathematical Modeling Lab, Engineering Faculty, University Campus Bio-Medico, Roma, Italy
[2]International Center for Relativistic Astrophysics, University of Rome La Sapienza, Roma, Italy
[3]Alberto Sordi Foundation, Research Institute on Aging, Roma, Italy

Postoperative or paralytic Ileus (PI) is a temporary aftermath of major abdominal surgeries. PI prevents the passage of food throughout the lumen leading to bloating, distension, emesis and pain. A plausible mathematical model for this phenomenology physiologically fine tuned including thermal variations, is presented here. Using COMSOL Multiphysics the existing intestinal ionic model have been ...

Inlay Fixed Partial Denture Framework 3-D Structural Integrity Validation Using COMSOL Multiphysics®

T.M.R. Alho[1]

[1]Department of Electrical Engineering and Automation, University of Vaasa, Vaasa, Finland

Manual manufacturing of inlay fixed partial denture frameworks by metal casting can take hours of dental practitioners work time. This paper introduces 3-D simulations of premanufactured inlay fixed partial denture framework assembled from laser cut sheet metal parts. The study gives a good estimation of how well the frameworks can withstand strong human occlusion forces and masticatory cycle. ...

Comparison of Computational Methods for the Estimation of the Dielectrophoretic Force Acting on Biological Cells and Aggregates in Silicon Lab-on-chip

S. Burgarella[1], F. Maggioni[2], and G. Naldi[2]
[1]STMicroelectronics, Agrate Brianza, Milan, Italy
[2]Department of Mathematics, University of Milan, Milan, Italy

Dielectrophoresis is a method for cell manipulation in miniaturized devices exploiting the dielectric properties of cells and/or cellular aggregates suspended in a fluid and subjected to a high-gradient electric field. The mathematical expression of the force is obtained by a multipole expansion whose terms involve increasing power of the particle\'s radius. Three methods for the expression ...

COMSOL Multiphysics® Model of Canine Elbow for Use in Investigating Medial Coronoid Disease

K. A. Bodnyk[1], G. J. Noble[1], N. Fitzpatrick[2], M. J. Allen[3], K. Stephenoff[1], R. T. Hart[1]
[1]Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA
[2]Fitzpatrick Referrals, Godalming, Surrey, United Kingdom
[3]Department of Veterinary Medicine, The Ohio State University, Columbus, OH, USA

The elbow joint in dogs constitutes a complex interaction of three bones, the humerus, radius and ulna. Medial coronoid disease (MCD) is a common cause of lameness in dogs, i.e. fracturing of the most prominent portion of the ulnar joint surface driven in flexion and in pivot against both the humerus and the radius. The cause remains unknown, but prior studies suggest joint incongruency as an ...

Microwave Exposure System for In Vitro and In Vivo Studies - new

C. Nadovich[1, 2], W. D. Jemison[2], J. A. Stoute[3], C. Spadafora[4]
[1]Lafayette College, Easton, PA, USA
[2]Clarkson University, Potsdam, NY, USA
[3]Pennsylvania State University, Hershey, PA, USA
[4]INDICASAT AIP, Ciudad del Saber, Panama

A computer controlled microwave exposure system and specialized applicators were constructed for the purpose of facilitating accurate observations of microwave radiation effects on uninfected and infected biological tissue in vitro and in vivo under different electromagnetic modalities and exposure configuration. To address diverse requirements, three different applicators were developed: a ...